在复杂系统环境中进行协同设计和开发实践的实在研究​​中的博士学位

拉夫堡大学在研究强度（REF2014）方面是英格兰排名前十的大学，并且有资格提交给REF的拉夫堡学术人员中有66％的杰出工作被评为“世界领先”。或“国际一流”，而全国平均水平为43％。<br>在选择拉夫堡进行研究时，您将与该领域的领导者一起工作。您将受益于我们的全面支持和指导，包括量身定制的职业建议，以帮助您在研究和未来职业中取得成功。<br>项目详情：21世纪面临着严峻的全球/社会挑战。系统工程系统（SoS）研究小组旨在通过研究和发展复杂的SoS工程以及塑造我们世界的社会技术系统来寻求解决这些挑战的方法
This PhD studentship seeks to apply state-of the art laser ablation technology developed at Loughborough University to improve understanding of heavy metal ions in biomaterials research. The development of medical devices such as total artificial hip implants and knee replacements in orthopaedic surgery and vascular stents in the treatment of cardiovascular disease has improved the quality of life of millions of people worldwide. However, their increasing use has raised concerns regarding the potential long-term side effects of implantable materials. Corrosion of metal-on-metal (MoM) hip implants may lead to leaching of toxic heavy metal ions and particulate materials known as wear debris in to the surrounding tissue. This has been associated with a variety of adverse tissue reactions. It is therefore important to develop an understanding of the extent of metal leaching and accumulation of particulate materials to inform safety procedures and facilitate the development of the next generation of improved biomaterials. The project will use laser ablation - inductively coupled plasma - mass spectrometry (LA-ICP-MS) to perform high resolution mapping of leached metals within samples that have been exposed to implantable materials. Loughborough University, in collaboration with industry, have developed a leading LA-ICP-MS system, which with its high speed, high sensitivity and sub-micron spatial resolution is ideally placed to characterise metal accumulation down to the single cell level.