干细胞生物学与再生医学哲学博士

我们的计划在基础科学和临床应用的交汇处提供高级培训，特别侧重于干细胞生物学和再生医学。该计划是国内外首个专门提供转化科学博士学位的课程之一。传统上，生物医学科学的博士课程集中在基础科学上，重点是诸如细菌，酵母，苍蝇，蠕虫，青蛙和小鼠等模型系统。此教育公式基于以下概念：与临床相关的发现自然会从基础科学中出现，人类有机体如此复杂以至于模型系统是可取的，并且对具有狭窄专业知识的科学家的需求将日益增长基础科学。很少强调基础科学发现的临床翻译。但是，随着近十年来新工具和技术的引入，很明显，人类生物学可以进行严格的研
Thesis research by SCBRM Ph.D. students spans the gamut from basic research to translational research, all with implications for stem cell biology and its applications to regenerative medicine. Our program is embracing the spirit of creativity and based on the principle that a detailed understanding of fundamental molecular and cellular mechanisms is the foundation for innovation in clinical translation. We also believe that basic scientists themselves are best at translating their own discoveries. Along those lines, our Ph.D. students explore fundamental mechanisms of how cells signal to one another, such as communication between stem cells and their niches, how the identities of various cell-types are established during development, from stem cells or by induced cellular reprogramming, and how aging occurs in animal models. They also develop efficient therapeutically relevant genome editing strategies, develop next generation, stem cell-based therapies, explore the inherited basis of complex human diseases by introducing genetic variants into cultured stem cells, and directed the in vitro differentiation of stem cells into therapeutically-valuable types of cells. SCBRM Ph.D. students are exposed to, and often exploit, the latest cutting-edge technologies including genome editing, single-cell transcriptional and chromatin analyses, cutting-edge microscopy and advanced stem cell culture systems. It is an exciting time to be immersed in stem cell research and regenerative medicine.