药理学哲学博士-分子与环境毒理学

药理学是一门涵盖了药物作用机理研究的健康科学，从在亚细胞水平的分子间和分子内反应到对整个生物体的生理系统的药物作用。毒理学通过了解由于暴露于药物，合成化学药品或天然产品而导致的正常结构或功能的变化，从而关系到人类，动物和环境的安全与健康。作为转化科学，药理学和毒理学采用了许多解剖学，生理学，生物化学，微生物学，免疫学，行为学和生物物理学的原理和方法。这些领域的研究进展使研究生课程能够在药理学和毒理学的各个子学科中提供训练有素的合格科学家。
The doctoral program in Pharmacology offers a Concentration in Molecular and Environmental Toxicology (MET). The mission of the MET concentration is to provide comprehensive cross-disciplinary Ph.D. doctoral training in environmental health science and modern-era molecular and cellular toxicology. To achieve this goal, the MET concentration offers interdisciplinary research opportunities and access to mentors who are dedicated to probing the complex effects of exposure to environmental stressors. The MET concentration emphasizes the use of contemporary approaches, such as advanced techniques in biochemistry, cell biology, molecular biology, molecular genomics, epigenetics, bioinformatics, proteomics, and epidemiology, in problems aimed at dissecting the mechanisms of environmentally-induced disease. MET scientists are studying intracellular signaling pathways, transcriptional regulation of gene expression, apoptosis, oxidative stress, DNA repair, epigenetic and genetic perturbations, and complex mechanisms in cell growth and differentiation that determine the environmental contribution to diseases with a rising incidence in the urban setting such as metabolic disease, cancer, immune system disturbances and mental health disorders.