Polycyclic ethers are a structurally intricate class of marine natural product possessing a general ladder-type structure of trans-fused polyether rings. There have been over twenty discovered with the first ground breaking total synthesis of hemibrevitoxin-B completed in 1992. Synthetic chemists were initially attracted by their unique structures, however, developments in the elucidation of their MOAs, (neurotoxicity, cytotoxicity) has emphasized the role these natural products can play in tackling many 21st Century health disorders, and therefore a medicinal drive to obtain workable amounts of material, efficiently, has become paramount. The predominant strategy used in their total synthesis is convergent, where the target molecule is disconnected into manageable fragments. The efficient synthesis of these fragments is fundamental in developing a successful total synthesis, where these fragments are coupled together yielding the target natural product. This research project will tackle the synthesis of gymnocin-B, the largest contiguous polycyclic ether discovered to-date, using a wholly original approach that harnesses inherent homology within its structure. Crucially, this approach provides two sizable fragments of gymnocin-B from one centrosymmetric, easily synthesized, precursor. It is expected results from this project will represent a step-change in the construction of polycyclic ethers. It will showcase innovative tactics in chemical synthesis, strategies and methodology that will have relevance to other complex polycyclic ether natural products, as well as providing an excellent training platform to the prospective PhD candidate in our new state-of-the-art laboratories here at Loughborough.