MRes临床化学

过去15年间，阿尔茨海默氏症研究英国（ARUK）的资金（320万英镑）使ARUK DNA银行（托管在诺丁汉）得以建立和维护。它目前包含6000多个样本，其中9个ARUK Network Group贡献了该样本。通过与Mayo诊所的Younkin教授的合作，我们可以获得额外的6000多个样本，从而获得了超过11,500的合并资源，这是世界上最大的资源之一。毫无疑问，该馆藏的主要贡献在于它在所有LOAD GWAS和ARUK外显子组测序项目中的使用，该项目自2009年以来发表了5篇《自然遗传学》论文和《新英格兰
Alzheimer's Research UK (ARUK) funding over the last 15 years (£3.2 million) has enabled the ARUK DNA bank (hosted at Nottingham) to be established and maintained. It currently contains over 6000 samples with contributions from nine ARUK Network Groups. As a result of collaboration with Professor Younkin at the Mayo Clinic, we have access to an additional 6000 plus samples resulting in a combined resource of over 11,500, one of the largest in the world. Without doubt the major contribution for the collection has been its use in all of the LOAD GWAS's and in the ARUK exome sequencing project, which has resulted in five Nature Genetics papers and a New England Journal of Medicine manuscript since 2009. We are actively involved in a number of projects addressing the genetics of Alzheimer's disease. The success of these approaches is evidenced by the 90 plus papers published in the last five years. We have run a number of LOAD, sEOAD, LBD and PCA samples on custom designed NeuroChip and are currently using this data to generate polygenic risk scores. We have access to GWAS, NGS and chip data from thousands of samples and this continues to be a rich resource to inform our future studies. We have also started to RNASeq from different brain regions in diseased and non-diseased tissue. In the future expansion of these types of study will empower us to use a systems approach to understand the pathogenesis of AD.