Unprecedented urbanization is impacting people and the planet from local to global scales. Multi-infrastructure systems-thinking and design innovations led by civil and environmental engineers are central to developing resilient, sustainable, healthy, livable and equitable urban futures. Faculty in this area explore human-infrastructure-environment interactions at multiple scales, advancing fundamental science, interdisciplinary urban-systems science, multi-infrastructure design and science-policy linkages. We study resource requirements of future urbanization, infrastructure transition pathways, and the response, recovery and adaptation of urban systems under multiple hazards. We connect cities to surrounding earth systems to mitigate extreme heat, wind, flooding and pollution. We develop integrated multi-infrastructure models that address the nexus of land, buildings, energy, water, food, and mobility systems. We design nature-based solutions and next-generation cyberphysical technologies. Collectively, this research informs critical emerging urban agendas, such as developing water-sensitive cities, net-zero carbon energy systems, resilient cities, healthy communities, and smart cities.