分子遗传学理学硕士-细胞和分子的结构与功能

分子遗传学系由医学大楼管理，有近100名教职员工，其实验室位于医学大楼内
The Department of Molecular Genetics is administered from the Medical Sciences Building and has nearly 100 faculty members whose labs are located within the Medical Science Building, the Best Institute, the Donnelly Centre for Cellular and Biomolecular Research, the FitzGerald Building, the Hospital for Sick Children, Mount Sinai Hospital, the Ontario Institute for Cancer Research, and Princess Margaret Hospital.<br>The Master of Science and Doctor of Philosophy programs in Molecular Genetics offer research training in a broad range of genetic systems from bacteria and viruses to humans. Research projects include DNA repair, recombination and segregation, transcription, RNA splicing and catalysis, regulation of gene expression, signal transduction, interactions of host cells with bacteria and viruses, developmental genetics of simple organisms (worms and fruit flies) as well as complex organisms (mice), molecular neurobiology, molecular immunology, cancer biology and virology, structural biology, and human genetics and gene therapy.<br>Our cellular and molecular structure and function research interests range from computational protein folding to stem cell biology. Despite the breadth, we can identify many themes, all of which centre on understanding fundamental mechanisms. Several labs focus on neuronal development and neuronal tissue function, such as the study of neuronal stem cell generation, axon guidance mechanisms, and the molecular basis for neural network formation. Central to these efforts is the study of stem cells and the use of several different animal models. We leverage cutting-edge techniques involving laser optics and optogenetics to study higher-order functions such as learning, memory and locomotion. We also use stem cells and animal models, including the zebrafish, to study development and disease in other systems and tissues, including the heart and kidney. Collectively, we expect the advances emerging from these efforts to contribute to novel approaches to treating neural and heart tissue damage, brain cancers in children and Alzheimer's disease in the elderly, to name just a few.