分子遗传学哲学博士-分子医学和人类遗传学

分子遗传学系由医学大楼管理，有近100名教职员工，其实验室位于医学大楼，最佳研究所，唐纳利细胞和生物分子研究中心，菲茨杰拉德大楼，病童医院，西奈山医院，安大略省癌症研究所和玛格丽特公主医院。分子遗传学的理学硕士和哲学博士课程为从细菌，病毒到人类的广泛遗传系统提供研究培训。研究项目包括DNA修复，重组和分离，转录，RNA剪接和催化，基因表达调控，信号转导，宿主细胞与细菌和病毒的相互作用，简单生物（蠕虫和果蝇）以及复杂生物的发育遗传学（小鼠），分子神经生物学，分子免疫学，癌症生物学和病毒学，结构生物学以及人类
The Department of Molecular Genetics is administered from the Medical Sciences Building and has nearly 100 faculty members whose labs are located within the Medical Science Building, the Best Institute, the Donnelly Centre for Cellular and Biomolecular Research, the FitzGerald Building, the Hospital for Sick Children, Mount Sinai Hospital, the Ontario Institute for Cancer Research, and Princess Margaret Hospital.<br>The Master of Science and Doctor of Philosophy programs in Molecular Genetics offer research training in a broad range of genetic systems from bacteria and viruses to humans. Research projects include DNA repair, recombination and segregation, transcription, RNA splicing and catalysis, regulation of gene expression, signal transduction, interactions of host cells with bacteria and viruses, developmental genetics of simple organisms (worms and fruit flies) as well as complex organisms (mice), molecular neurobiology, molecular immunology, cancer biology and virology, structural biology, and human genetics and gene therapy.<br>A new era in medical intervention is on the horizon, enabled by revolutionary advances in genetics and genomics. The Human Genome Project has changed our approach to biology and medicine. As the power of the genome sequence became evident, technologies have also rapidly advanced, allowing sequence data from individuals to be acquired at a phenomenal pace and at increasingly lower costs. Massively parallel sequencing (also known as next generation, or NextGen, sequencing) has ushered in the era of genomic and genetic medicine. Now, equipped with the genome sequence of a patient, scientists can diagnose genetic disease, identify future disease risk, home in on disease modifiers and predict responses to drugs. Researchers in the Department of Molecular Genetics have led the world in identification of single genes that, when mutated, cause diseases such as cystic fibrosis, Duchenne muscular dystrophy, myotonic dystrophy, neurofibromatosis, and retinoblastoma. Now, researchers elucidate the more complex genetic basis of many multi-gene major disabling and fatal diseases including autism, muscular dystrophies, heart disease, stroke, diabetes, and several kinds of cancer. The identification of disease-association genes and their products will facilitate a better understanding of their function, as it paves the way towards effective diagnostics, therapeutics and preventative measures.