分子遗传学哲学博士-细胞和分子的结构与功能

分子遗传学系由医学大楼管理，有近100名教职员工，其实验室位于医学大楼，最佳研究所，唐纳利细胞和生物分子研究中心，菲茨杰拉德大楼，病童医院，西奈山医院，安大略省癌症研究所和玛格丽特公主医院。分子遗传学的理学硕士和哲学博士课程为从细菌，病毒到人类的广泛遗传系统提供研究培训。研究项目包括DNA修复，重组和分离，转录，RNA剪接和催化，基因表达调控，信号转导，宿主细胞与细菌和病毒的相互作用，简单生物（蠕虫和果蝇）以及复杂生物的发育遗传学（小鼠），分子神经生物学，分子免疫学，癌症生物学和病毒学，结构生物学以及人类
The Department of Molecular Genetics is administered from the Medical Sciences Building and has nearly 100 faculty members whose labs are located within the Medical Science Building, the Best Institute, the Donnelly Centre for Cellular and Biomolecular Research, the FitzGerald Building, the Hospital for Sick Children, Mount Sinai Hospital, the Ontario Institute for Cancer Research, and Princess Margaret Hospital.<br>The Master of Science and Doctor of Philosophy programs in Molecular Genetics offer research training in a broad range of genetic systems from bacteria and viruses to humans. Research projects include DNA repair, recombination and segregation, transcription, RNA splicing and catalysis, regulation of gene expression, signal transduction, interactions of host cells with bacteria and viruses, developmental genetics of simple organisms (worms and fruit flies) as well as complex organisms (mice), molecular neurobiology, molecular immunology, cancer biology and virology, structural biology, and human genetics and gene therapy.<br>Our research interests in the area of Cellular and Molecular Structure and Function range from computational protein folding to stem cell biology. Despite the breadth, there are a number of themes that can be identified, all of which are centred on understanding fundamental mechanisms. Several labs are focussed on neuronal development and neuronal tissue function, for example, work that includes the study of neuronal stem cell generation, axon guidance mechanisms and the molecular basis for neural network formation. Central to these efforts is the study of stem cells and the use of a number of different animal models. Cutting-edge techniques involving laser optics and optogenetics are leveraged to study higher-order functions such as learning, memory and locomotion. Stem cells and animal models, including the zebra fish, are also being used to study development and disease in other systems and tissues including the heart and kidney. Collectively, the advances emerging from these efforts are expected to contribute to novel approaches to treating neural and heart tissue damage, brain cancers in children and Alzheimer's disease in the elderly to name just a few. Genome stability through successive cell divisions is central to the maintenance of normal cellular function. Not surprisingly, DNA damage and the gain or loss of chromosomes or portions of them are hallmarks of cancer. Several MoGen labs are working to understand DNA repair mechanisms and the processes that ensure proper chromosome replication and segregation. In one collaborative effort, functional genomics, microscopy and mass-spectrometry are being used to study centrosome biogenesis, an important component in the regulation of cell division. In another collaboration, cell-based approaches and x-ray crystallography are utilized to determine how DNA repair enzymes are recruited to double-strand breaks.