分子遗传学哲学博士-分子微生物学和传染病

分子遗传学系由医学大楼管理，有近100名教职员工，其实验室位于医学大楼，最佳研究所，唐纳利细胞和生物分子研究中心，菲茨杰拉德大楼，病童医院，西奈山医院，安大略省癌症研究所和玛格丽特公主医院。分子遗传学的理学硕士和哲学博士课程为从细菌，病毒到人类的广泛遗传系统提供研究培训。研究项目包括DNA修复，重组和分离，转录，RNA剪接和催化，基因表达调控，信号转导，宿主细胞与细菌和病毒的相互作用，简单生物（蠕虫和果蝇）以及复杂生物的发育遗传学（小鼠），分子神经生物学，分子免疫学，癌症生物学和病毒学，结构生物学以及人类
The Department of Molecular Genetics is administered from the Medical Sciences Building and has nearly 100 faculty members whose labs are located within the Medical Science Building, the Best Institute, the Donnelly Centre for Cellular and Biomolecular Research, the FitzGerald Building, the Hospital for Sick Children, Mount Sinai Hospital, the Ontario Institute for Cancer Research, and Princess Margaret Hospital.<br>The Master of Science and Doctor of Philosophy programs in Molecular Genetics offer research training in a broad range of genetic systems from bacteria and viruses to humans. Research projects include DNA repair, recombination and segregation, transcription, RNA splicing and catalysis, regulation of gene expression, signal transduction, interactions of host cells with bacteria and viruses, developmental genetics of simple organisms (worms and fruit flies) as well as complex organisms (mice), molecular neurobiology, molecular immunology, cancer biology and virology, structural biology, and human genetics and gene therapy.<br>MoGen research in the area of Molecular Microbiology and Infectious Disease tackles fundamental questions as to the molecular mechanisms that bacteria, fungi, and viruses employ to achieve their biotic prowess. We aim to understand how pathogens manipulate the host to replicate and cause disease, and how the host recognizes, captures, and destroys invading pathogens. We also study basic cellular processes such as genome replication, regulation of gene expression, and responses to stress and environmental cues. This understanding will be critical in enabling us to address global challenges including the development of new strategies to cripple HIV, prevent and treat tuberculosis, halt the spread of sexually transmitted disease, and conquer Legionnaire's Disease, invasive fungal infections, and microbial drug resistance. Research in microbiology and infectious disease is undergoing a renaissance over the past decade. Microbes exist in overwhelming numbers and unparalleled diversity, and we now appreciate their profound impact on the planet and on human health and disease. The human body contains over 10 times more microbial cells than human cells, with members of the human microbiome being implicated in a multitude of conditions including obesity, diabetes, rheumatoid arthritis, muscular dystrophy, multiple sclerosis, and cancer. Some microbes are pathogens and can cause life-threatening infectious disease. These pathogens pose one of the greatest threats to human health worldwide, at least in part because they rapidly evolve resistance to the drugs we use to kill them. We are now in jeopardy of entering a post-antibiotic era, in which common infections that were once treatable will become lethal due to widespread multi-drug resistance.