分子遗传学哲学博士-计算和系统生物学

分子遗传学系由医学大楼管理，有近100名教职员工，其实验室位于医学大楼，最佳研究所，唐纳利细胞和生物分子研究中心，菲茨杰拉德大楼，病童医院，西奈山医院，安大略省癌症研究所和玛格丽特公主医院。分子遗传学的理学硕士和哲学博士课程为从细菌，病毒到人类的广泛遗传系统提供研究培训。研究项目包括DNA修复，重组和分离，转录，RNA剪接和催化，基因表达调控，信号转导，宿主细胞与细菌和病毒的相互作用，简单生物（蠕虫和果蝇）以及复杂生物的发育遗传学（小鼠），分子神经生物学，分子免疫学，癌症生物学和病毒学，结构生物学以及人类
The Department of Molecular Genetics is administered from the Medical Sciences Building and has nearly 100 faculty members whose labs are located within the Medical Science Building, the Best Institute, the Donnelly Centre for Cellular and Biomolecular Research, the FitzGerald Building, the Hospital for Sick Children, Mount Sinai Hospital, the Ontario Institute for Cancer Research, and Princess Margaret Hospital.<br>The Master of Science and Doctor of Philosophy programs in Molecular Genetics offer research training in a broad range of genetic systems from bacteria and viruses to humans. Research projects include DNA repair, recombination and segregation, transcription, RNA splicing and catalysis, regulation of gene expression, signal transduction, interactions of host cells with bacteria and viruses, developmental genetics of simple organisms (worms and fruit flies) as well as complex organisms (mice), molecular neurobiology, molecular immunology, cancer biology and virology, structural biology, and human genetics and gene therapy.<br>Computational Biology seeks to help understand biological systems using computational methods that can take advantage of large and complex data being increasingly generated by genomics technologies. Systems Biology studies biological systems as a whole, considering properties not apparent when examining one component at a time, and requires a combination of experimental and computational methods to map and understand these complex systems. Computational and Systems Biology are often combined and share the goals of understanding how biological systems work at the cellular and molecular level, how these systems may break to cause disease and how to fix these failures and develop useful therapies. Amazing progress has been made in this field recently, taking advantage of exponentially increasing data measuring many aspects of biological systems. An entire cell has recently been simulated and hundreds of thousands of genomes are being used to map mutations causing thousands of diseases. Molecular Genetics researchers in Computational and Systems Biology have made major progress on understanding alternative splicing, discovered thousands of novel protein interactions and complexes, mapped new metabolic pathways, discovered mutations that underlie a range of human diseases, including cancer, found new pathways of therapeutic vulnerability in pathogens and created the first complete genetic interaction map of a cell, substantially improving our understanding of basic genetics.