PhD / DM Neurology-临床神经病学

临床神经病学研究小组的主要兴趣是多发性硬化症（MS）。我们调查了干扰素1型（IFN）（一种MS治疗）和白介素12（IL-12）（一种对MS有害的促炎细胞因子）的矛盾信号通路。我们显示，当被IFN和IL-12激活时，不同因素对途径的调节不同，并且MS患者具有固有的IFN信号缺陷。我们表明，星形胶质细胞可以表达并产生IL-12家族细胞因子的大多数元素。我们已经显示类固醇诱导保护自身免疫的调节性T（Treg）细胞，以及类固醇和IFN诱导Treg细胞主要转录因子foxp3的诱导。我们调查IL-12如何抑制Treg
The Clinical Neurology Research Group's main interest is multiple sclerosis (MS). We investigated paradoxically shared signalling pathways for interferon type 1 (IFN), an MS treatment, and interleukin-12 (IL-12), a proinflammatory cytokine detrimental in MS. We showed that different factors modulate the pathway differently when activated by IFN and IL-12, and that MS patients have an intrinsic IFN signalling deficit. We showed that astrocytes can express and produce most elements of the IL-12 family of cytokines. We have shown induction of regulatory T (Treg) cells that protect against autoimmunity, by steroids, and induction of the main transcription factor for Treg cells, foxp3, by steroids and IFN. We investigate how IL-12 suppresses signalling pathways essential for Treg function.